Researchers Design Artificial Cells that Can Communicate

Microcapsules in “snake” formation as competing signaling capsules (shown in red) pull respective lines of target cells in opposite directions.

Inspired by the social interactions of ants and slime molds, University of Pittsburgh engineers have designed artificial cells capable of self-organising into independent groups that can communicate and cooperate. Recently reported in the Proceedings of the National Academy of Sciences (PNAS), the research is said to be a significant step toward producing synthetic cells that behave like natural organisms and could perform important, microscale functions in fields ranging from the chemical industry to medicine.

The team presents in the PNAS paper computational models that provide a blueprint for developing artificial cells—or microcapsules—that can communicate, move independently, and transport “cargo” such as chemicals needed for reactions. Most importantly, the “biologically inspired” devices function entirely through simple physical and chemical processes, behaving like complex natural organisms but without the complicated internal biochemistry, says corresponding author Anna Balazs, a professor of chemical engineering at the university.

The group’s microcapsules interact by secreting nanoparticles in a way similar to that used by biological cells signal to communicate and assemble into groups. And with a nod to ants, the cells leave chemical trails as they travel, prompting fellow microcapsules to follow. Balazs worked with lead author German Kolmakov and Victor Yashin, both postdoctoral researchers at the university, who produced the cell models; and with professor of electrical and computer engineering Steven Levitan, who devised the ant-like trailing ability.

The researchers write that communication hinges on the interaction between microcapsules exchanging two different types of nanoparticles. The “signalling” cell secretes nanoparticles known as agonists that prompt the second “target” microcapsule to emit nanoparticles known as antagonists.

More information on the research is available from the University of Pittsburgh.

Tags: artificial cells, Proceedings of the National Academy of Sciences, University of Pittsburgh