Digital Reconstruction of Tissue Enables 3-D Virtual Microscopy

April 23, 2012 – 4:28 pm

A virtual microscopy method developed at University of Leeds allows for the 3-D viewing of tissue samples.

Researchers at University of Leeds have created a digital scanning system of tissue samples that allows for 3-D reconstruction of tissue. Conventional microscopy does not allow for true 3-D analysis, as users examine ultrathin tissue samples one-by-one. The system developed at University of Leeds turns hundreds of slides into high-resolution digital images that are aligned using image registration software.

The automated system turns slides into images with very little manual input required. It allows users to zoom into areas of interest to view the shape and structure of cells, blood vessels and tumours. The images can be rotated and examined from any angle. The technique could have applications both in research and clinical settings.

The study was funded by the UK National Cancer Research Institute informatics initiative, the UK Department of Health, Leeds Teaching Hospital Trust Research and Development, UK National Institute for Health Research and West Yorkshire Comprehensive Local Research Network. It was published in the May issue of the American Journal of Pathology.

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